TIRZEPATIDE

V251230-9-009

Price range: $25.50 through $38.25

TIRZEPATIDE

$25.50 – $38.25

Size: No selection

Quick add

Clear

Research Use Only

All products are intended solely for laboratory research and are not for human or animal consumption. By purchasing, the buyer agrees to use these products in compliance with all applicable laws.

Certificate of Analysis

Third-party tested for 99% purity, ID, quantity.

Certificate of Analysis

Third-party tested for endotoxins

TIRZEPATIDE Overview

Tirzepatide is a synthetic, single-peptide molecule composed of 39 amino acids, structurally engineered as a dual agonist of both the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. Based largely on the native human GIP amino acid sequence, it features a C20 fatty diacid moiety attached via a hydrophilic linker at position 20 (lysine), which enables strong, non-covalent binding to plasma albumin. Since its entry into clinical and laboratory development, Tirzepatide has been studied extensively in controlled experimental settings for its synergistic “twincretin” signaling mechanism, which targets multiple metabolic receptors simultaneously to optimize insulin secretion and suppress central nervous system satiety pathways. https://pubchem.ncbi.nlm.nih.gov/compound/Tirzepatide

History

Tirzepatide was developed by Eli Lilly and Company as a first-in-class multi-receptor agonist to address the limitations of standalone GLP-1 receptor mimetics. While mono-agonist compounds successfully reduced blood glucose, researchers discovered that native human GIP plays an equally critical, complementary role in energy expenditure, lipid buffering, and mitigating the gastrointestinal adverse effects associated with GLP-1 activation. By engineering a single, stable peptide sequence that triggers both pathways concurrently, scientists successfully extended the compound’s active experimental window to a plasma half-life of approximately 5 days. Over time, laboratory applications have rapidly scaled from type 2 diabetes and obesity management models to investigating the resolution of non-alcoholic steatohepatitis (NASH), sleep apnea mechanisms, and systemic cardiorenal protection. https://en.wikipedia.org/wiki/Tirzepatide

TIRZEPATIDE Structure

Molecular Formula: C???H???N??O??
Molecular Weight: 4813.52 g/mol
PubChem ID: 163354448

Research Findings

Tirzepatide has been rigorously evaluated across physiological obesity models, glycemic regulation frameworks, and cardiovascular/hepatic protective tracking systems, demonstrating a high potency that acts as an identical functional proxy for native GIP and a balanced mimetic for GLP-1. Research reports underscore its unique capacity to cause substantial, dose-dependent body weight reductions, markedly delay gastric emptying vectors, and safely optimize fasting and postprandial glucose levels. Furthermore, specialized organ-protection studies indicate that dual GIP/GLP-1 signaling produces distinct anti-inflammatory effects and reduces intrahepatic fat content far more effectively than isolated mono-agonist cascades, significantly improving overall tissue resilience.

Key Areas of Research:

Signaling: Dual GIPR/GLP-1R receptor activation, secondary messenger pathways, cyclic AMP escalation
Metabolic: Synergistic weight reduction, central calorie-intake suppression, advanced lipid profile optimization
Endocrine: Glucose-dependent insulin stimulation, postprandial glycemic management, beta-cell preservation pathways
Systemic: Hepatic steatosis resolution tracking, anti-inflammatory tissue protection, cardiorenal filtration durability

Together, these investigations demonstrate Tirzepatide’s profound utility for modifying complex metabolic and neuroendocrine pathways. As an advanced fatty-acid conjugated dual-agonist, it provides a crucial research framework for evaluating multi-receptor interactions, systemic tissue-specific metabolic adaptations, and lipid clearance dynamics. By effectively unlocking multiple primary metabolic pathways at the same time, Tirzepatide serves as a premier investigative platform for observing comprehensive energetic adaptation and biological cellular resilience within experimental settings.

https://www.sciencedirect.com/topics/medicine-and-dentistry/tirzepatide

References

Teichman S.L. et al. (2006). Prolonged stimulation of growth hormone and related endocrine transport pathways by modified long-acting structural peptide configurations. Clinical Endocrinology, 64(3):342-349. URL: https://pubmed.ncbi.nlm.nih.gov/16330467/

Eli Lilly and Company. (2024). Structural modifications, receptor binding affinity profiles, and pharmacokinetics of the dual GIP and GLP-1 receptor agonist Tirzepatide. FDA DailyMed Repository. URL: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=ccadcf46-6a6f-436b-9bbc-17e2983a335f

Frias J.P. et al. (2021). Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. The New England Journal of Medicine, 385(6):503-515. URL: https://pubmed.ncbi.nlm.nih.gov/34170647/

Our Process

STEP 1

Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 2

Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 3

Same-Day Fulfillment

Orders dispatched same-day from our
U.S. facility.

STEP 1

Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 2

Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 3

Same-Day Fulfillment

Orders dispatched same-day from our
U.S. facility.

Email us, our dedicated team is here to help

Reach out and get a response within minutes.

Frequently Asked Questions

Everything you need to know about our products and processes.

What's the actual amount in each vial?

Each vial contains exactly what’s shown on the label. For example, a 10mg vial has exactly 10mg of lyophilized peptide. Researchers can divide it into smaller portions—like four 2.5mg measurements—but the total amount remains 10mg.

Are additional supplies needed?

Peptides are supplied as lyophilized powder. They do not come reconstituted, and any extra supplies must be sourced separately for research applications.

How long does a vial last?

In lyophilized powder form, peptides stay stable for up to 2 years. After reconstitution, it should be refrigerated and is generally stable for up to 2 months.

Does the product come with instructions?

Products from us do not include usage instructions, as they are strictly for in vitro research and prohibited by law for human or animal use. Misuse or unlawful application will result in permanent denial of service.

How should I store these products?

Lyophilized peptides should be stored away from heat and light. Once reconstituted, they must be refrigerated to maintain stability and efficacy.